Childhood Cancer Survivorship
Over the past decades, survival rates for childhood cancer have dramatically increased, with over 300,000 long-term survivors alive today. Despite this success, survivors continue to face elevated risks for late-effects, including secondary cancers, although the magnitude of their impact on life-expectancy has not been quantified. To generate estimates of the cumulative impact of excess mortality risks on survivors’ health, we synthesized the best available long-term follow-up data on five-year childhood cancer survivors using a mathematical model. We found that disease and treatment-related late-effects may substantially reduce survivor life expectancy. Our findings underscore the importance for proactive health monitoring of this growing population of cancer survivors and the pressing need to minimize therapies with known late toxicities in patients newly diagnosed with childhood cancer.