HSPH Adjunct Professor Uwe Siebert spoke at a CHDS lunchtime seminar on the potential bias that can accompany the use of “real world” evidence in modeling. Using a case study in ovarian cancer treatment, Siebert identified a range of methodological challenges for evaluating causality in this context, including confounding, missing/misclassified data, lack of clear treatment assignment, dynamic treatment regimens, and switching. Siebert explained a method of obtaining valid using the “target trial concept” along with casual methods adjusting for time-dependent confounding.
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